Adenovirus expressing dual c-Met-specific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescence-like phenotypes in glioblastoma cells

c-Met, a cognate receptor tyrosine kinase of hepatocyte growth factor, is overexpressed and/or mutated in number of tumors. Therefore, abrogation of c-Met signaling may serve as potential therapeutic targets. In this study, we generated Ads expressing single shRNA specific to c-Met (shMet) (dl/shMet...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jung-Sun, Oh, Eonju, Yoo, Ji Young, Choi, Kyeong Sook, Yoon, Mi Jin, Yun, Chae-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414172/
https://www.ncbi.nlm.nih.gov/pubmed/25726528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414172/
https://www.ncbi.nlm.nih.gov/pubmed/25726528

Ejemplares similares