An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation

BACKGROUND: The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for proliferation. However, dependence on increased PHGDH expression extends beyond...

Descripción completa

Detalles Bibliográficos
Autores principales: Mattaini, Katherine R, Brignole, Edward J, Kini, Mitali, Davidson, Shawn M, Fiske, Brian P, Drennan, Catherine L, Vander Heiden, Matthew G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414297/
https://www.ncbi.nlm.nih.gov/pubmed/25926973
http://dx.doi.org/10.1186/s40170-015-0131-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414297/
https://www.ncbi.nlm.nih.gov/pubmed/25926973
http://dx.doi.org/10.1186/s40170-015-0131-7

Ejemplares similares