An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation

BACKGROUND: The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for proliferation. However, dependence on increased PHGDH expression extends beyond...

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Detalles Bibliográficos
Autores principales: Mattaini, Katherine R, Brignole, Edward J, Kini, Mitali, Davidson, Shawn M, Fiske, Brian P, Drennan, Catherine L, Vander Heiden, Matthew G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414297/
https://www.ncbi.nlm.nih.gov/pubmed/25926973
http://dx.doi.org/10.1186/s40170-015-0131-7

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