Target Modulation by a Kinase Inhibitor Engineered to Induce a Tandem Blockade of the Epidermal Growth Factor Receptor (EGFR) and c-Src: The Concept of Type III Combi-Targeting

Cancer cells are characterized by a complex network of interrelated and compensatory signaling driven by multiple kinases that reduce their sensitivity to targeted therapy. Therefore, strategies directed at inhibiting two or more kinases are required to robustly block the growth of refractory tumour...

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Detalles Bibliográficos
Autores principales: Rao, Suman, Larroque-Lombard, Anne-Laure, Peyrard, Lisa, Thauvin, Cédric, Rachid, Zakaria, Williams, Christopher, Jean-Claude, Bertrand J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414309/
https://www.ncbi.nlm.nih.gov/pubmed/25658745
http://dx.doi.org/10.1371/journal.pone.0117215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414309/
https://www.ncbi.nlm.nih.gov/pubmed/25658745
http://dx.doi.org/10.1371/journal.pone.0117215

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