Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors

The β-lactam cholesterol absorption inhibitor ezetimibe is so far the only representative of this class of compounds on the market today. The goal of this work was to synthesize new amide ezetimibe analogs from trans-3-amino-(3R,4R)-β-lactam and to test their cytotoxicity and activity as cholesterol...

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Detalles Bibliográficos
Autores principales: Dražić, Tonko, Sachdev, Vinay, Leopold, Christina, Patankar, Jay V., Malnar, Martina, Hećimović, Silva, Levak-Frank, Sanja, Habuš, Ivan, Kratky, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414353/
https://www.ncbi.nlm.nih.gov/pubmed/25882530
http://dx.doi.org/10.1016/j.bmc.2015.03.067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414353/
https://www.ncbi.nlm.nih.gov/pubmed/25882530
http://dx.doi.org/10.1016/j.bmc.2015.03.067

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