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Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors
The β-lactam cholesterol absorption inhibitor ezetimibe is so far the only representative of this class of compounds on the market today. The goal of this work was to synthesize new amide ezetimibe analogs from trans-3-amino-(3R,4R)-β-lactam and to test their cytotoxicity and activity as cholesterol...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414353/ https://www.ncbi.nlm.nih.gov/pubmed/25882530 http://dx.doi.org/10.1016/j.bmc.2015.03.067 |