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Osteoarthritis-dependent changes in antinociceptive action of Na(v)1.7 and Na(v)1.8 sodium channel blockers: An in vivo electrophysiological study in the rat
Voltage-gated sodium channel blockers are not traditionally recommended for osteoarthritis (OA) pain therapy, but given the large peripheral drive that follows OA development there is a rationale for their use. Using a rat model of monosodium iodoacetate (MIA)-induced OA we used in vivo electrophysi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414363/ https://www.ncbi.nlm.nih.gov/pubmed/25818052 http://dx.doi.org/10.1016/j.neuroscience.2015.03.042 |