Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells

We reported that knockdown of PPP2R5C by siRNA led to proliferation inhibition and apoptosis induction in K562 cells. In this study, we further characterized the gene expression profiles after PPP2R5C suppression by microarray analysis. Genes which participate in the MAPK, PI3K/AKT, and JAK/STAT pat...

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Autores principales: Liu, Sichu, Shen, Qi, Chen, Yu, Zeng, Chengwu, Cao, Changshu, Yang, Lijian, Chen, Shaohua, Wu, Xiuli, Li, Bo, Li, Yangqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414434/
https://www.ncbi.nlm.nih.gov/pubmed/25888193
http://dx.doi.org/10.1186/s13045-015-0125-5
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author Liu, Sichu
Shen, Qi
Chen, Yu
Zeng, Chengwu
Cao, Changshu
Yang, Lijian
Chen, Shaohua
Wu, Xiuli
Li, Bo
Li, Yangqiu
author_facet Liu, Sichu
Shen, Qi
Chen, Yu
Zeng, Chengwu
Cao, Changshu
Yang, Lijian
Chen, Shaohua
Wu, Xiuli
Li, Bo
Li, Yangqiu
author_sort Liu, Sichu
collection PubMed
description We reported that knockdown of PPP2R5C by siRNA led to proliferation inhibition and apoptosis induction in K562 cells. In this study, we further characterized the gene expression profiles after PPP2R5C suppression by microarray analysis. Genes which participate in the MAPK, PI3K/AKT, and JAK/STAT pathways, were mainly altered in the K562 cells. We propose that the mechanism for proliferation inhibition and increased apoptosis of K562 cells following PPP2R5C suppression may be related to the alteration of expression profiles of BRAF, AKT2, AKT3, NFKB2 and STAT3 genes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-015-0125-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-44144342015-04-30 Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells Liu, Sichu Shen, Qi Chen, Yu Zeng, Chengwu Cao, Changshu Yang, Lijian Chen, Shaohua Wu, Xiuli Li, Bo Li, Yangqiu J Hematol Oncol Letter to the Editor We reported that knockdown of PPP2R5C by siRNA led to proliferation inhibition and apoptosis induction in K562 cells. In this study, we further characterized the gene expression profiles after PPP2R5C suppression by microarray analysis. Genes which participate in the MAPK, PI3K/AKT, and JAK/STAT pathways, were mainly altered in the K562 cells. We propose that the mechanism for proliferation inhibition and increased apoptosis of K562 cells following PPP2R5C suppression may be related to the alteration of expression profiles of BRAF, AKT2, AKT3, NFKB2 and STAT3 genes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-015-0125-5) contains supplementary material, which is available to authorized users. BioMed Central 2015-04-12 /pmc/articles/PMC4414434/ /pubmed/25888193 http://dx.doi.org/10.1186/s13045-015-0125-5 Text en © Liu et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Liu, Sichu
Shen, Qi
Chen, Yu
Zeng, Chengwu
Cao, Changshu
Yang, Lijian
Chen, Shaohua
Wu, Xiuli
Li, Bo
Li, Yangqiu
Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells
title Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells
title_full Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells
title_fullStr Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells
title_full_unstemmed Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells
title_short Alteration of gene expression profile following PPP2R5C knockdown may be associated with proliferation suppression and increased apoptosis of K562 cells
title_sort alteration of gene expression profile following ppp2r5c knockdown may be associated with proliferation suppression and increased apoptosis of k562 cells
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414434/
https://www.ncbi.nlm.nih.gov/pubmed/25888193
http://dx.doi.org/10.1186/s13045-015-0125-5
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