Cooperative loss of RAS feedback regulation drives myeloid leukemognesis

RAS network activation is common in human cancers and, in acute myeloid leukemia (AML), achieved mainly through gain-of-function mutations in KRAS, NRAS, or the FLT3 receptor tyrosine kinase(1). In mice, we show that premalignant myeloid cells harboring a Kras(G12D) allele retain low Ras signaling o...

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Detalles Bibliográficos
Autores principales: Zhao, Zhen, Chen, Chi-Chao, Rillahan, Cory D., Shen, Ronglai, Kitzing, Thomas, McNerney, Megan E., Diaz-Flores, Ernesto, Zuber, Johannes, Shannon, Kevin, Le Beau, Michelle M., Spector, Mona S., Kogan, Scott C., Lowe, Scott W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414804/
https://www.ncbi.nlm.nih.gov/pubmed/25822087
http://dx.doi.org/10.1038/ng.3251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414804/
https://www.ncbi.nlm.nih.gov/pubmed/25822087
http://dx.doi.org/10.1038/ng.3251

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