Functional annotation of native enhancers with a Cas9 -histone demethylase fusion

Understanding of mammalian enhancer function is limited by the lack of a technology to rapidly and thoroughly test their cell type-specific function. Here, we use a nuclease-deficient (d)Cas9 histone demethylase fusion to functionally characterize previously described and novel enhancer elements for...

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Detalles Bibliográficos
Autores principales: Kearns, Nicola A, Pham, Hannah, Tabak, Barbara, Genga, Ryan M, Silverstein, Noah J, Garber, Manuel, Maehr, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414811/
https://www.ncbi.nlm.nih.gov/pubmed/25775043
http://dx.doi.org/10.1038/nmeth.3325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414811/
https://www.ncbi.nlm.nih.gov/pubmed/25775043
http://dx.doi.org/10.1038/nmeth.3325

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