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Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrP(Sc) over time
Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation on soil, two PrP(Sc) phenotypes were present: G(3...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415298/ https://www.ncbi.nlm.nih.gov/pubmed/25928902 http://dx.doi.org/10.1186/s13567-015-0179-y |