Activation of Sonic Hedgehog Leads to Survival Enhancement of Astrocytes via the GRP78-Dependent Pathway in Mice Infected with Angiostrongylus cantonensis

Angiostrongylus cantonensis infection may cause elevation of ROS and antioxidants in the CSF of infected mice. Astrocytes may protect the surrounding neurons from oxidative stress-induced cell death by secreting Sonic hedgehog (Shh) via the PI3-K/AKT/Bcl-2 pathway. This study was conducted to determ...

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Detalles Bibliográficos
Autores principales: Chen, Kuang-Yao, Cheng, Chien-Ju, Wang, Lian-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415671/
https://www.ncbi.nlm.nih.gov/pubmed/25961032
http://dx.doi.org/10.1155/2015/674371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415671/
https://www.ncbi.nlm.nih.gov/pubmed/25961032
http://dx.doi.org/10.1155/2015/674371

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