Lipophilic Triphenylphosphonium Cations Inhibit Mitochondrial Electron Transport Chain and Induce Mitochondrial Proton Leak

BACKGROUND: The lipophilic positively charged moiety of triphenylphosphonium (TPP(+)) has been used to target a range of biologically active compounds including antioxidants, spin-traps and other probes into mitochondria. The moiety itself, while often considered biologically inert, appears to influ...

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Detalles Bibliográficos
Autores principales: Trnka, Jan, Elkalaf, Moustafa, Anděl, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415762/
https://www.ncbi.nlm.nih.gov/pubmed/25927600
http://dx.doi.org/10.1371/journal.pone.0121837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415762/
https://www.ncbi.nlm.nih.gov/pubmed/25927600
http://dx.doi.org/10.1371/journal.pone.0121837

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