Cargando…
Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma
Neuroblastoma (NB), although rare, accounts for 15% of all paediatric cancer mortality. Unusual among cancers, NBs lack a consistent set of gene mutations and, excluding large-scale chromosomal rearrangements, the genome seems to be largely intact. Indeed, many interesting features of NB suggest tha...
Autores principales: | Wylie, Luke A., Hardwick, Laura J. A., Papkovskaia, Tatiana D., Thiele, Carol J., Philpott, Anna |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415893/ https://www.ncbi.nlm.nih.gov/pubmed/25786414 http://dx.doi.org/10.1242/dmm.018630 |
Ejemplares similares
-
The N terminus of Ascl1 underlies differing proneural activity of mouse and
Xenopus Ascl1 proteins
por: Hardwick, Laura J.A., et al.
Publicado: (2018) -
Interaction between opposing modes of phospho-regulation of the proneural proteins Ascl1 and Ngn2
por: Hardwick, Laura J.A., et al.
Publicado: (2018) -
Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo
por: Ghazale, Hussein, et al.
Publicado: (2022) -
The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma
por: Parkinson, Lydia M., et al.
Publicado: (2022) -
Xenopus as a developmental model of neuroblastoma
Publicado: (2015)