Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers

Despite their value as sources of therapeutic drug targets, membrane proteomes are largely inaccessible to high-throughput screening (HTS) tools designed for soluble proteins. An important example comprises the membrane proteins that bind amyloid β oligomers (AβOs). AβOs are neurotoxic ligands thoug...

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Detalles Bibliográficos
Autores principales: Wilcox, Kyle C., Marunde, Matthew R., Das, Aditi, Velasco, Pauline T., Kuhns, Benjamin D., Marty, Michael T., Jiang, Haoming, Luan, Chi-Hao, Sligar, Stephen G., Klein, William L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415972/
https://www.ncbi.nlm.nih.gov/pubmed/25928376
http://dx.doi.org/10.1371/journal.pone.0125263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415972/
https://www.ncbi.nlm.nih.gov/pubmed/25928376
http://dx.doi.org/10.1371/journal.pone.0125263

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