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Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers
Despite their value as sources of therapeutic drug targets, membrane proteomes are largely inaccessible to high-throughput screening (HTS) tools designed for soluble proteins. An important example comprises the membrane proteins that bind amyloid β oligomers (AβOs). AβOs are neurotoxic ligands thoug...
Autores principales: | Wilcox, Kyle C., Marunde, Matthew R., Das, Aditi, Velasco, Pauline T., Kuhns, Benjamin D., Marty, Michael T., Jiang, Haoming, Luan, Chi-Hao, Sligar, Stephen G., Klein, William L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415972/ https://www.ncbi.nlm.nih.gov/pubmed/25928376 http://dx.doi.org/10.1371/journal.pone.0125263 |
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