Genetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes

Despite large-scale cancer genomics studies, key somatic mutations driving cancer, and their functional roles, remain elusive. Here we propose that analysis of comorbidities of Mendelian diseases with cancers provides a novel, systematic way to discover new cancer genes. If germline genetic variatio...

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Detalles Bibliográficos
Autores principales: Melamed, Rachel D., Emmett, Kevin J., Madubata, Chioma, Rzhetsky, Andrey, Rabadan, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416231/
https://www.ncbi.nlm.nih.gov/pubmed/25926297
http://dx.doi.org/10.1038/ncomms8033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416231/
https://www.ncbi.nlm.nih.gov/pubmed/25926297
http://dx.doi.org/10.1038/ncomms8033

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