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Enzyme Architecture: Optimization of Transition State Stabilization from a Cation–Phosphodianion Pair
[Image: see text] The side chain cation of R269 lies at the surface of l-glycerol 3-phosphate dehydrogenase (GPDH) and forms an ion pair to the phosphodianion of substrate dihydroxyacetone phosphate (DHAP), which is buried at the nonpolar protein interior. The R269A mutation of GPDH results in a 110...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416717/ https://www.ncbi.nlm.nih.gov/pubmed/25884759 http://dx.doi.org/10.1021/jacs.5b02202 |