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Enzyme Architecture: Optimization of Transition State Stabilization from a Cation–Phosphodianion Pair

[Image: see text] The side chain cation of R269 lies at the surface of l-glycerol 3-phosphate dehydrogenase (GPDH) and forms an ion pair to the phosphodianion of substrate dihydroxyacetone phosphate (DHAP), which is buried at the nonpolar protein interior. The R269A mutation of GPDH results in a 110...

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Detalles Bibliográficos
Autores principales:	Reyes, Archie C., Koudelka, Astrid P., Amyes, Tina L., Richard, John P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416717/ https://www.ncbi.nlm.nih.gov/pubmed/25884759 http://dx.doi.org/10.1021/jacs.5b02202

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