Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport

It is essential to establish a useful validation method for newly generated humanized mouse models. The novel approach of combining our established species-specific protein quantification method combined with in vivo functional studies is evaluated to validate a humanized mouse model of P-gp/MDR1 ef...

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Detalles Bibliográficos
Autores principales: Sadiq, Muhammad Waqas, Uchida, Yasuo, Hoshi, Yutaro, Tachikawa, Masanori, Terasaki, Tetsuya, Hammarlund-Udenaes, Margareta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416786/
https://www.ncbi.nlm.nih.gov/pubmed/25932627
http://dx.doi.org/10.1371/journal.pone.0118638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416786/
https://www.ncbi.nlm.nih.gov/pubmed/25932627
http://dx.doi.org/10.1371/journal.pone.0118638

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