DBA/2J Genetic Background Exacerbates Spontaneous Lethal Seizures but Lessens Amyloid Deposition in a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a leading cause of dementia in the elderly and is characterized by amyloid plaques, neurofibrillary tangles (NFTs) and neuronal dysfunction. Early onset AD (EOAD) is commonly caused by mutations in amyloid precursor protein (APP) or genes involved in the processing of APP...

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Detalles Bibliográficos
Autores principales: Jackson, Harriet M., Onos, Kristen D., Pepper, Keating W., Graham, Leah C., Akeson, Ellen C., Byers, Candice, Reinholdt, Laura G., Frankel, Wayne N., Howell, Gareth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416920/
https://www.ncbi.nlm.nih.gov/pubmed/25933409
http://dx.doi.org/10.1371/journal.pone.0125897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416920/
https://www.ncbi.nlm.nih.gov/pubmed/25933409
http://dx.doi.org/10.1371/journal.pone.0125897

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