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Global variability in gene expression and alternative splicing is modulated by mitochondrial content

Noise in gene expression is a main determinant of phenotypic variability. Increasing experimental evidence suggests that genome-wide cellular constraints largely contribute to the heterogeneity observed in gene products. It is still unclear, however, which global factors affect gene expression noise...

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Detalles Bibliográficos
Autores principales: Guantes, Raul, Rastrojo, Alberto, Neves, Ricardo, Lima, Ana, Aguado, Begoña, Iborra, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417112/
https://www.ncbi.nlm.nih.gov/pubmed/25800673
http://dx.doi.org/10.1101/gr.178426.114