Aptamer-Mediated Codelivery of Doxorubicin and NF-κB Decoy Enhances Chemosensitivity of Pancreatic Tumor Cells

Aptamers able to bind efficiently cell-surface receptors differentially expressed in tumor and in healthy cells are emerging as powerful tools to perform targeted anticancer therapy. Here, we present a novel oligonucleotide chimera, composed by an RNA aptamer and a DNA decoy. Our assembly is able to...

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Detalles Bibliográficos
Autores principales: Porciani, David, Tedeschi, Lorena, Marchetti, Laura, Citti, Lorenzo, Piazza, Vincenzo, Beltram, Fabio, Signore, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417125/
https://www.ncbi.nlm.nih.gov/pubmed/25919089
http://dx.doi.org/10.1038/mtna.2015.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417125/
https://www.ncbi.nlm.nih.gov/pubmed/25919089
http://dx.doi.org/10.1038/mtna.2015.9

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