A rapid and sensitive high-throughput screening method to identify compounds targeting protein–nucleic acids interactions

DNA-binding and RNA-binding proteins are usually considered ‘undruggable’ partly due to the lack of an efficient method to identify inhibitors from existing small molecule repositories. Here we report a rapid and sensitive high-throughput screening approach to identify compounds targeting protein–nu...

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Detalles Bibliográficos
Autores principales: Alonso, Nicole, Guillen, Roboan, Chambers, Jeremy W., Leng, Fenfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417145/
https://www.ncbi.nlm.nih.gov/pubmed/25653160
http://dx.doi.org/10.1093/nar/gkv069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417145/
https://www.ncbi.nlm.nih.gov/pubmed/25653160
http://dx.doi.org/10.1093/nar/gkv069

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