The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures

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G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation. Despite the important roles that G-quadruplexes play in telomere biology and gene transcription, neither the impact of guanine lesions on the stability of quadruplexes nor their repair are well understood....

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Detalles Bibliográficos
Autores principales: Zhou, Jia, Fleming, Aaron M., Averill, April M., Burrows, Cynthia J., Wallace, Susan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417164/
https://www.ncbi.nlm.nih.gov/pubmed/25813041
http://dx.doi.org/10.1093/nar/gkv252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417164/
https://www.ncbi.nlm.nih.gov/pubmed/25813041
http://dx.doi.org/10.1093/nar/gkv252

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