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Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects
Mutation rates are used to calibrate molecular clocks and to link genetic variants with human disease. However, mutation rates are not uniform across each eukaryotic genome. Rates for insertion/deletion (indel) mutations have been found to vary widely when examined in vitro and at specific loci in v...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417177/ https://www.ncbi.nlm.nih.gov/pubmed/25824945 http://dx.doi.org/10.1093/nar/gkv271 |