Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?

Non D-loop direct repeats (DRs) in mitochondrial DNA (mtDNA) have been commonly implicated in the mutagenesis of mtDNA deletions associated with neuromuscular disease and ageing. Further, these DRs have been hypothesized to put a constraint on the lifespan of mammals and are under a negative selecti...

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Detalles Bibliográficos
Autores principales: Lakshmanan, Lakshmi Narayanan, Gruber, Jan, Halliwell, Barry, Gunawan, Rudiyanto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417187/
https://www.ncbi.nlm.nih.gov/pubmed/25855815
http://dx.doi.org/10.1093/nar/gkv299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417187/
https://www.ncbi.nlm.nih.gov/pubmed/25855815
http://dx.doi.org/10.1093/nar/gkv299

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