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Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?
Non D-loop direct repeats (DRs) in mitochondrial DNA (mtDNA) have been commonly implicated in the mutagenesis of mtDNA deletions associated with neuromuscular disease and ageing. Further, these DRs have been hypothesized to put a constraint on the lifespan of mammals and are under a negative selecti...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417187/ https://www.ncbi.nlm.nih.gov/pubmed/25855815 http://dx.doi.org/10.1093/nar/gkv299 |