DNA Methylation and Histone Modifications Are the Molecular Lock in Lentivirally Transduced Hematopoietic Progenitor Cells

Stable introduction of a functional gene in hematopoietic progenitor cells (HPCs) has appeared to be an alternative approach to correct genetically linked blood diseases. However, it is still unclear whether lentiviral vector (LV) is subjected to gene silencing in HPCs. Here, we show that LV carryin...

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Detalles Bibliográficos
Autores principales: Ngai, Siew Ching, Rosli, Rozita, Al Abbar, Akram, Abdullah, Syahril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417590/
https://www.ncbi.nlm.nih.gov/pubmed/25961011
http://dx.doi.org/10.1155/2015/346134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417590/
https://www.ncbi.nlm.nih.gov/pubmed/25961011
http://dx.doi.org/10.1155/2015/346134

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