How Proteins Bind Macrocycles

The potential utility of synthetic macrocycles as drugs, particularly against low druggability targets such as protein-protein interactions, has been widely discussed. There is little information, however, to guide the design of macrocycles for good target protein-binding activity or bioavailability...

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Detalles Bibliográficos
Autores principales: Villar, Elizabeth A., Beglov, Dmitri, Chennamadhavuni, Spandan, Porco, John A., Kozakov, Dima, Vajda, Sandor, Whitty, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417626/
https://www.ncbi.nlm.nih.gov/pubmed/25038790
http://dx.doi.org/10.1038/nchembio.1584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417626/
https://www.ncbi.nlm.nih.gov/pubmed/25038790
http://dx.doi.org/10.1038/nchembio.1584

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