Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model

MCPH1, also known as BRIT1, has recently been identified as a novel key regulatory gene of the DNA damage response pathway. MCPH1 is located on human chromosome 8p23.1, where human cancers frequently show loss of heterozygosity. As such, MCPH1 is aberrantly expressed in many malignancies, including...

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Detalles Bibliográficos
Autores principales: Liang, Yulong, Gao, Hong, Lin, Shiaw-Yih, Goss, John A., Du, Chunying, Li, Kaiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417661/
https://www.ncbi.nlm.nih.gov/pubmed/25362854
http://dx.doi.org/10.1038/onc.2014.367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417661/
https://www.ncbi.nlm.nih.gov/pubmed/25362854
http://dx.doi.org/10.1038/onc.2014.367

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