Role of Acidic Residues in Helices TH8–TH9 in Membrane Interactions of the Diphtheria Toxin T Domain

The pH-triggered membrane insertion of the diphtheria toxin translocation domain (T domain) results in transferring the catalytic domain into the cytosol, which is relevant to potential biomedical applications as a cargo-delivery system. Protonation of residues is suggested to play a key role in the...

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Detalles Bibliográficos
Autores principales: Ghatak, Chiranjib, Rodnin, Mykola V., Vargas-Uribe, Mauricio, McCluskey, Andrew J., Flores-Canales, Jose C., Kurnikova, Maria, Ladokhin, Alexey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417968/
https://www.ncbi.nlm.nih.gov/pubmed/25875295
http://dx.doi.org/10.3390/toxins7041303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417968/
https://www.ncbi.nlm.nih.gov/pubmed/25875295
http://dx.doi.org/10.3390/toxins7041303

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