A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis

BACKGROUND: Intracerebral infection of susceptible mouse strains with Theiler’s murine encephalomyelitis virus (TMEV) results in chronic demyelinating disease with progressive axonal loss and neurologic dysfunction similar to progressive forms of multiple sclerosis (MS). We previously showed that as...

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Detalles Bibliográficos
Autores principales: Wootla, Bharath, Denic, Aleksandar, Watzlawik, Jens O, Warrington, Arthur E, Rodriguez, Moses
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418041/
https://www.ncbi.nlm.nih.gov/pubmed/25924771
http://dx.doi.org/10.1186/s12974-015-0303-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418041/
https://www.ncbi.nlm.nih.gov/pubmed/25924771
http://dx.doi.org/10.1186/s12974-015-0303-y

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