Crystalline silica-induced leukotrieneB(4)-dependent inflammation promotes lung tumor growth

Chronic exposure to crystalline silica (CS) causes silicosis, an irreversible lung inflammatory disease that may eventually lead to lung cancer. In this study, we demonstrate that in K-ras(LA1) mice, CS exposure markedly enhances the lung tumor burden and genetic deletion of leukotriene B(4) recepto...

Descripción completa

Detalles Bibliográficos
Autores principales: Satpathy, Shuchismita R., Jala, Venkatakrishna R., Bodduluri, Sobha R., Krishnan, Elangovan, Hegde, Bindu, Hoyle, Gary, Fraig, Mostafa, Luster, Andrew D., Haribabu, Bodduluri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418220/
https://www.ncbi.nlm.nih.gov/pubmed/25923988
http://dx.doi.org/10.1038/ncomms8064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418220/
https://www.ncbi.nlm.nih.gov/pubmed/25923988
http://dx.doi.org/10.1038/ncomms8064

Ejemplares similares