Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction

Interstrand crosslinks induce DNA replication fork stalling that in turn activates the ATR-dependent checkpoint and DNA repair on nuclear chromatin. Mitomycin C (MC) and Decarbamoyl Mitomycin C (DMC) induce different types of DNA crosslinks with DMC being a more cytotoxic agent. We previously report...

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Detalles Bibliográficos
Autores principales: Xiao, Gu, Kue, Pao, Bhosle, Rahul, Bargonetti, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418290/
https://www.ncbi.nlm.nih.gov/pubmed/25565400
http://dx.doi.org/10.1080/15384101.2014.997517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418290/
https://www.ncbi.nlm.nih.gov/pubmed/25565400
http://dx.doi.org/10.1080/15384101.2014.997517

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