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The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2
It is currently accepted that superoxide anion (O(2) (•−)) is an important mediator in pain and inflammation. The role of superoxide anion in pain and inflammation has been mainly determined indirectly by modulating its production and inactivation. Direct evidence using potassium superoxide (KO(2)),...
Autores principales: | Maioli, N.A., Zarpelon, A.C., Mizokami, S.S., Calixto-Campos, C., Guazelli, C.F.S., Hohmann, M.S.N., Pinho-Ribeiro, F.A., Carvalho, T.T., Manchope, M.F., Ferraz, C.R., Casagrande, R., Verri, W.A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Associação Brasileira de Divulgação Científica
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418362/ https://www.ncbi.nlm.nih.gov/pubmed/25714890 http://dx.doi.org/10.1590/1414-431X20144187 |
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