IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk

BACKGROUND: Mast cell localization within the airway smooth muscle (ASM)-bundle plays an important role in the development of airway hyper-responsiveness (AHR). Genomewide association studies implicate the ‘alarmin’ IL-33 in asthma, but its role in mast cell–ASM interactions is unknown. OBJECTIVES:...

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Detalles Bibliográficos
Autores principales: Kaur, D, Gomez, E, Doe, C, Berair, R, Woodman, L, Saunders, R, Hollins, F, Rose, FR, Amrani, Y, May, R, Kearley, J, Humbles, A, Cohen, ES, Brightling, CE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418379/
https://www.ncbi.nlm.nih.gov/pubmed/25683166
http://dx.doi.org/10.1111/all.12593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418379/
https://www.ncbi.nlm.nih.gov/pubmed/25683166
http://dx.doi.org/10.1111/all.12593

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