Protective Effects of Valproic Acid, a Histone Deacetylase Inhibitor, against Hyperoxic Lung Injury in a Neonatal Rat Model

OBJECTIVE: Histone acetylation and deacetylation may play a role in the pathogenesis of inflammatory lung diseases. We evaluated the preventive effect of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, on neonatal hyperoxic lung injury. METHODS: Forty newborn rat pups were randomized in...

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Detalles Bibliográficos
Autores principales: Cetinkaya, Merih, Cansev, Mehmet, Cekmez, Ferhat, Tayman, Cuneyt, Canpolat, Fuat Emre, Kafa, Ilker Mustafa, Yaylagul, Esra Orenlili, Kramer, Boris W., Sarici, Serdar Umit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418724/
https://www.ncbi.nlm.nih.gov/pubmed/25938838
http://dx.doi.org/10.1371/journal.pone.0126028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418724/
https://www.ncbi.nlm.nih.gov/pubmed/25938838
http://dx.doi.org/10.1371/journal.pone.0126028

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