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Prostaglandin D(2) and leukotriene E(4) synergize to stimulate diverse T(H)2 functions and T(H)2 cell/neutrophil crosstalk
BACKGROUND: Prostaglandin D(2) (PGD(2)) and cysteinyl leukotrienes (cysLTs) are lipid mediators derived from mast cells, which activate T(H)2 cells. The combination of PGD(2) and cysLTs (notably cysteinyl leukotriene E(4) [LTE(4)]) enhances T(H)2 cytokine production. However, the synergistic interac...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mosby
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418751/ https://www.ncbi.nlm.nih.gov/pubmed/25441644 http://dx.doi.org/10.1016/j.jaci.2014.09.006 |