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Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion
Several studies indicate that the activity of cruzipain, the main lysosomal cysteine peptidase of Trypanosoma cruzi, contributes to parasite infectivity. In addition, the parasitic invasion process of mammalian host cells is described to be dependent on the activation of the host TGF-β signaling pat...
Autores principales: | Ferrão, Patrícia Mello, d'Avila-Levy, Claudia Masini, Araujo-Jorge, Tania Cremonini, Degrave, Wim Maurits, Gonçalves, Antônio da Silva, Garzoni, Luciana Ribeiro, Lima, Ana Paula, Feige, Jean Jacques, Bailly, Sabine, Mendonça-Lima, Leila, Waghabi, Mariana Caldas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418758/ https://www.ncbi.nlm.nih.gov/pubmed/25938232 http://dx.doi.org/10.1371/journal.pone.0124832 |
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