Blocking anaplerotic entry of glutamine to TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs

Cancer cells undergo a metabolic transformation that allows for increased anabolic demands wherein glycolytic and TCA cycle intermediates are shunted away for the synthesis of biological molecules required for cell growth and division. One of the key shunts is the exit of citrate from the mitochondr...

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Detalles Bibliográficos
Autores principales: Saqcena, Mahesh, Mukhopadhyay, Suman, Hosny, Carol, Alhamed, Arwa, Chatterjee, Amrita, Foster, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418945/
https://www.ncbi.nlm.nih.gov/pubmed/25023699
http://dx.doi.org/10.1038/onc.2014.207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418945/
https://www.ncbi.nlm.nih.gov/pubmed/25023699
http://dx.doi.org/10.1038/onc.2014.207

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