Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling

JAK-STAT signaling mediates the actions of numerous cytokines and growth factors, and its endogenous brake is the family of SOCS proteins. Consistent with their intracellular roles, SOCS proteins have never been identified in the extracellular space. Here we report that alveolar macrophages can secr...

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Detalles Bibliográficos
Autores principales: Bourdonnay, Emilie, Zasłona, Zbigniew, Penke, Loka Raghu Kumar, Speth, Jennifer M., Schneider, Daniel J., Przybranowski, Sally, Swanson, Joel A., Mancuso, Peter, Freeman, Christine M., Curtis, Jeffrey L., Peters-Golden, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419346/
https://www.ncbi.nlm.nih.gov/pubmed/25847945
http://dx.doi.org/10.1084/jem.20141675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419346/
https://www.ncbi.nlm.nih.gov/pubmed/25847945
http://dx.doi.org/10.1084/jem.20141675

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