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Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2
BACKGROUND: Kinase activity of cGMP-dependent, type II, protein kinase (PRKG2) is required for the proliferative to hypertrophic transition of growth plate chondrocytes during endochondral ossification. Loss of PRKG2 function in rodent and bovine models results in dwarfism. The objective of this stu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419418/ https://www.ncbi.nlm.nih.gov/pubmed/25924610 http://dx.doi.org/10.1186/s13104-015-1136-6 |