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Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines
The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an S(N)2-type ring opening followed by cyclization of the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419545/ https://www.ncbi.nlm.nih.gov/pubmed/25977727 http://dx.doi.org/10.3762/bjoc.11.59 |
| Sumario: | The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an S(N)2-type ring opening followed by cyclization of the resulting haloalkoxy amine. |
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