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8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction
Small molecule nonpeptidic mimics of α-helices are widely recognised as protein-protein interaction (PPIs) inhibitors. Protein-protein interactions mediate virtually all important regulatory pathways in a cell, and the ability to control and modulate PPIs is therefore of great significance to basic...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420247/ https://www.ncbi.nlm.nih.gov/pubmed/25942498 http://dx.doi.org/10.1371/journal.pone.0124423 |