Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity

Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic activity of the hybrid organic-inorganic (zidovudine derivatives-silica) systems against HeLa and KB cell lines has been analyzed. Addition of folic...

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Detalles Bibliográficos
Autores principales: Lewandowski, Dawid, Lewandowska, Marta, Ruszkowski, Piotr, Pińska, Anita, Schroeder, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420263/
https://www.ncbi.nlm.nih.gov/pubmed/25942021
http://dx.doi.org/10.1371/journal.pone.0126251
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author Lewandowski, Dawid
Lewandowska, Marta
Ruszkowski, Piotr
Pińska, Anita
Schroeder, Grzegorz
author_facet Lewandowski, Dawid
Lewandowska, Marta
Ruszkowski, Piotr
Pińska, Anita
Schroeder, Grzegorz
author_sort Lewandowski, Dawid
collection PubMed
description Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic activity of the hybrid organic-inorganic (zidovudine derivatives-silica) systems against HeLa and KB cell lines has been analyzed. Addition of folic acid had a positive influence on the cytotoxicity. Up to 69% of HeLa and 65% of KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg/mL).
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spelling pubmed-44202632015-05-12 Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity Lewandowski, Dawid Lewandowska, Marta Ruszkowski, Piotr Pińska, Anita Schroeder, Grzegorz PLoS One Research Article Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic activity of the hybrid organic-inorganic (zidovudine derivatives-silica) systems against HeLa and KB cell lines has been analyzed. Addition of folic acid had a positive influence on the cytotoxicity. Up to 69% of HeLa and 65% of KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg/mL). Public Library of Science 2015-05-05 /pmc/articles/PMC4420263/ /pubmed/25942021 http://dx.doi.org/10.1371/journal.pone.0126251 Text en © 2015 Lewandowski et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lewandowski, Dawid
Lewandowska, Marta
Ruszkowski, Piotr
Pińska, Anita
Schroeder, Grzegorz
Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity
title Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity
title_full Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity
title_fullStr Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity
title_full_unstemmed Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity
title_short Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity
title_sort immobilization of zidovudine derivatives on the sba-15 mesoporous silica and evaluation of their cytotoxic activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420263/
https://www.ncbi.nlm.nih.gov/pubmed/25942021
http://dx.doi.org/10.1371/journal.pone.0126251
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