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Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC

The establishment of apical-basolateral polarity is important for both normal development and disease, for example, during tumorigenesis and metastasis. During this process, polarity complexes are targeted to the apical surface by a RAB11A-dependent mechanism. Huntingtin (HTT), the protein that is m...

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Detalles Bibliográficos
Autores principales: Elias, Salah, McGuire, John Russel, Yu, Hua, Humbert, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420272/
https://www.ncbi.nlm.nih.gov/pubmed/25942483
http://dx.doi.org/10.1371/journal.pbio.1002142