Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape

A diverse subset of pattern recognition receptors (PRRs) detects pathogen-associated nucleic acids to initiate crucial innate immune responses in host organisms. Reflecting their importance for host defense, pathogens encode various countermeasures to evade or inhibit these immune effectors. PRRs di...

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Detalles Bibliográficos
Autores principales: Hancks, Dustin C., Hartley, Melissa K., Hagan, Celia, Clark, Nathan L., Elde, Nels C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420275/
https://www.ncbi.nlm.nih.gov/pubmed/25942676
http://dx.doi.org/10.1371/journal.pgen.1005203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420275/
https://www.ncbi.nlm.nih.gov/pubmed/25942676
http://dx.doi.org/10.1371/journal.pgen.1005203

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