Bias in Ligation-Based Small RNA Sequencing Library Construction Is Determined by Adaptor and RNA Structure

High-throughput sequencing (HTS) has become a powerful tool for the detection of and sequence characterization of microRNAs (miRNA) and other small RNAs (sRNA). Unfortunately, the use of HTS data to determine the relative quantity of different miRNAs in a sample has been shown to be inconsistent wit...

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Detalles Bibliográficos
Autores principales: Fuchs, Ryan T., Sun, Zhiyi, Zhuang, Fanglei, Robb, G. Brett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420488/
https://www.ncbi.nlm.nih.gov/pubmed/25942392
http://dx.doi.org/10.1371/journal.pone.0126049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420488/
https://www.ncbi.nlm.nih.gov/pubmed/25942392
http://dx.doi.org/10.1371/journal.pone.0126049

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