Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia

Aberrant activation of the Wnt pathway plays a pathogenetic role in tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). Lymphoid enhancer binding factor 1 (LEF1), a key mediator of Wnt signaling, has been linked to leukemic transformation, and LEF1 mutations ha...

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Detalles Bibliográficos
Autores principales: Guo, Xing, Zhang, Run, Liu, Juan, Li, Min, Song, Chunhua, Dovat, Sinisa, Li, Jianyong, Ge, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420493/
https://www.ncbi.nlm.nih.gov/pubmed/25942645
http://dx.doi.org/10.1371/journal.pone.0125429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420493/
https://www.ncbi.nlm.nih.gov/pubmed/25942645
http://dx.doi.org/10.1371/journal.pone.0125429

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